Proviron (Mesterolone) Steroid Profile
Table of Contents
- Profile Of Proviron / Mesterolone
- Overview And History of Proviron / Mesterolone
- Chemistry Behind Proviron/ Mesterolone
- Effects Of Proviron/ Mesterolone
- Side Effects of Proviron/ Mesterolone
- Cycles And Usage of Proviron/ Mesterolone
- Dosage & Administration of Proviron / Mesterolone
- How To Buy Proviron/ Mesterolone
Profile Of Proviron / Mesterolone
- Structure: [1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one]
- Molecular Weight: 304.4716
- Molecular Formula: C20H32O2
- Melting Point: N/A
- Manufacturer: Schering
- Release Date: 1960
- Effective Dose: 25-200mgs/day
- Active Life: up to 12 hours
- Detection Time: 5-6 weeks
- Anabolic/Androgenic Ratio: 100-150:30-40
Overview And History of Proviron / Mesterolone
Proviron is one of the most well-known anabolic androgenic steroids available. It began in 1934 as a product of Schering, the world's largest pharmaceutical firm. Officially known as Mesterolone, it has been marketed under a variety of brand names throughout the years, but Proviron has remained the most popular. Among steroid users, it is also one of the most misunderstood anabolic steroids.
Proviron is a one-of-a-kind anabolic steroid in many respects. It resembles Masteron (Drostanolone) and, to a lesser extent, Anavar (Oxandrolone) and Winstrol (Stanozolol), but it is a whole other species. Proviron is not utilized in a performance capacity to stimulate substantial bulk gains, while it can be useful during this period of training. Proviron, on the other hand, will be significantly more prevalent in cutting cycles, although its role will be relatively distinct once again.
Proviron is one of the most regularly utilized anabolic steroids in modern medicine as a medicinal medication. The Mesterolone hormone, on the other hand, has never been authorized by the FDA in the United States. It is largely used in European medicine, particularly in Western Europe. The major goal of usage is to treat androgen deficiency, which is most commonly caused by old age. It is, however, also employed in boys in their prepubescent years. The hormone is also used as a fertility aid in men and this alone makes it a very unique anabolic steroid as most anabolic steroids tend to have the opposite effect.
Proviron's usage as a fertility aid was heavily promoted in the medical literature. This is because, whereas practically other anabolic/androgenic steroids are known to induce temporary infertility, Proviron rarely lowers endogenous gonadotropins (LH and FSH) when used at typical therapeutic doses. Proviron, on the other hand, is often misinterpreted as a chemical that boosts LH production, which it does not. Proviron, on the other hand, has been shown to give the androgenic effects required for spermatogenesis in certain parts of the testes.
Mesterolone is still manufactured by Schering today under the brand name Proviron all over the world. Pluriviron (in Germany by Asche), Vistimon (in Germany by Jenepharm), and Restore are some of the brand names that have been used (in India, by Brown and Burke
Chemistry Behind Proviron/ Mesterolone
Mesterolone is a dihydrotestosterone (DHT) derived anabolic androgenic steroid. Specifically, it is a structurally altered DHT hormone possessing the addition of a methyl group at the carbon one position. This allows the hormone to survive oral ingestion by protecting it from hepatic breakdown. This is one of the only oral anabolic steroids that are not C17-alpha-alkylated (C17-aa) but instead carry the added methyl group.
Studies have demonstrated the reason for its weak anabolic effects: it shares with its parent compound (DHT) a similar property – it is rapidly metabolized and broken down into inactive metabolites once it enters muscle tissue. This has always been the problem with dihydrotestosterone itself – once it enters muscle tissue, the enzyme 3-hydroxysteroid dehydrogenase (where it is in very high concentration in muscle tissue) binds to it and renders it inactive by converting it into a compound that has no anabolic effects.
This is the real reason for Proviron’s weak anabolic effects. An added benefit of Proviron is its ability to have a high affinity for SHBG (Sex Hormone Binding Globulin), which is a protein that binds to anabolic steroids in the bloodstream (namely, Testosterone) and renders them completely inactive once bound. A well-known benefit of Proviron is also its ability to act as an anti-estrogen via its activity as an aromatase inhibitor.
Proviron carries an androgenic rating of 30-40 and an anabolic rating of 100-150. Despite having an anabolic rating that is potentially greater than testosterone, Proviron will display very low anabolic traits. This is very similar to Halotestin (Fluoxymesterone), which carries a massive anabolic rating but very little translatable anabolic activity.
In the case of Proviron, while structurally very anabolic, the Mesterolone hormone converts and reduces to Diol metabolites, in turn reducing anabolic activity. In fact, its translatable androgenic activity appears to commonly be higher than its structural rating would imply.
On a functional basis, Proviron carries four primary traits that largely define its mode of action. Proviron also has the ability to interact with the aromatase enzyme, the enzyme responsible for the conversion of testosterone to estrogen. By binding to the aromatase enzyme, Proviron can actually inhibit aromatase activity, thereby offering protection against estrogenic side effects. It will not carry an anti-estrogenic effect near the level of power of an Aromatase Inhibitor (AI) but it will be notable. The Mesterolone hormone will also carry a strong binding affinity to the androgen receptor. Once again this will promote the functionality of other steroids to a degree but more importantly promote enhanced metabolic activity through direct lipolysis. Before we go any further understand Proviron does have the ability to suppress gonadotropins, but there’s a line that has to be crossed for notable suppression to interfere with sperm production.
Effects Of Proviron/ Mesterolone
During a bulking phase, Proviron is not going to be a foundational steroid, and for most men, it will not have a place in an off-season cycle. Adding in Proviron could possibly help the individual break through a sticking point during his cycle. By the way, Proviron enhances the total free state of the other steroids being used in a stack, it could possibly help the individual breakthrough this sticking point.
Many will use large amounts during cutting cycles too, especially competitive bodybuilders but lower testosterone plans are more common during the cutting phase. However, there are those for numerous reasons who choose to run off-season cycles with limited testosterone doses.
Without question, the best time to use Proviron will be during the cutting phase. Then we consider its strong binding to the androgen receptor, which will in fact enable the individual to burn body fat at a far more efficient rate. This will ensure the individual is less prone to water retention and as discussed, depending on the total cycle, it could negate the need for a traditional anti-estrogen.
This can be a tremendous benefit when testosterone levels are often much lower during this phase of anabolic steroid use. In fact, with a low-dosed testosterone cycle that includes other anabolic steroids, we can confidently say the total results will be greater for the individual who includes Proviron compared to the one who does not.
Side Effects of Proviron/ Mesterolone
Because Proviron is a DHT derivative, it poses no danger of estrogenic adverse effects at any dosage. Proviron operates as an anti-estrogen in the body by inhibiting the enzyme aromatase. Lowering overall circulating plasma levels of Estrogen can help to mitigate estrogenic negative effects from other medicines.
Because of this impact, Proviron has been used therapeutically in the treatment of gynecomastia and breast malignancies due to its strong androgenic nature paired with its anti-estrogenic properties, according to research.
Because Proviron is predominantly an androgen, it carries the potential of androgenic side effects, which are more noticeable at larger doses. The following are some of Proviron's androgenic adverse effects: greasy skin (due to increased sebum production/secretion), increased facial and body hair development, and an increased risk of MPB (Male Pattern Baldness) in individuals who are genetically sensitive or susceptible to it.
Women are also susceptible to virilization, which is the development of masculine traits in females, as a result of the usage of Proviron (i.e., deepening of the voice, facial hair growth, enlargement of the clitoris, etc.). It's also worth noting that, because Proviron is already a DHT derivative, medicines like Finasteride, Proscar, or Dutasteride will have no effect on Proviron's possible androgenic adverse effects.
Proviron does not create hepatotoxic effects since it is not C-17 alpha alkylated (rather, it is methylation on its first carbon), thus liver issues are exceedingly improbable with this chemical.
However, Proviron's adverse effects include detrimental effects on the cardiovascular system. According to studies, taking 100mg of Proviron daily for 6 months has a considerable unfavorable impact on cholesterol levels, raising bad (LDL) cholesterol by 65 percent and reducing good (HDL) cholesterol by 35 percent, respectively.
Proviron is also thought to have a suppressive impact on endogenous Testosterone production (though this is considered to be very weak.
Studies have shown that taking 150mg or less of Proviron per day has no effect on Testosterone levels. Higher doses (300mg or higher per day) led to a considerable reduction in Testosterone levels in the same trials.
Cycles And Usage of Proviron/ Mesterolone
Proviron isn't used in cycles since it isn't an anabolic steroid with very mild anabolic effects. In order to decrease or moderate the effects of Estrogen on the body, it is usually used as an auxiliary chemical in conjunction with anabolic steroid cycles. It's also employed for its cosmetic benefits in boosting the physique's 'hard' appearance, thanks to its anti-estrogen and high androgen properties.
It can be used by male athletes and bodybuilders at 50–100mg per day as an auxiliary throughout the duration of their cycle, as there is no restriction to how long it can be used. Some people opt to use Proviron as a PCT (Post Cycle Therapy) medication to lower Estrogen levels and increase fertility. Although this is possible, there are many superior drugs for PCT that have comparable (and greater) benefits.
When the danger of even mild endogenous Testosterone suppression is added to the equation, it is recommended that Proviron not be used for PCT unless no other choices are available. Any threat to endogenous Testosterone synthesis, no matter how little, should be unwelcomed and avoided at all costs during a period when individuals are seeking to regain their normal endogenous Testosterone levels.
Dosage & Administration of Proviron / Mesterolone
Proviron dosages for treating androgen or male fertility are usually between 50 and 75 mg per day. The complete dosage is usually divided into 2-3 25mg doses each day. The overall dose in androgen deficiency regimens nearly always starts at 75mg per day and gradually decreases to 25-50mg per day, depending on the patient's needs.
Proviron dosages in a performance capacity typically vary from 50 to 150 mg per day. Most men, on the other hand, will find that 100mg per day is the bare minimum, with both 100mg and 150mg is highly effective. The average duration of usage is 8-12 weeks. However, if you're trying to break past a cycle's sticking point, say near the conclusion, a 6-week course of Proviron could help.
When considering how to take Proviron, keep in mind that it stacks well with all anabolic steroids. It works best when used with anabolic steroids like Anavar, Masteron, and Winstrol, as well as Primobolan, during the cutting phase.
It will considerably increase the androgenicity of these steroids in order to achieve and maintain the desired hard appearance. While it will stack well with any anabolic steroids during a bulking phase, it's difficult to determine if you'll need it or not. Some people will simply keep it on hand and use it when it proves to be necessary.
How To Buy Proviron/ Mesterolone
Although Proviron is not as well-known as other compounds, ancillaries, or anabolic steroids, it is nevertheless considered a staple item and should be easily found on most source lists of items available for purchase. There is an underground lab (UGL) generated items in addition to pharmaceutical-grade products.
Proviron is known to be created by certain well-known underground laboratories, although it is unlikely that lesser-known (or smaller) UGLs will do so because it is not as popular as other goods or ancillaries. Pharmaceutical-grade materials Proviron will always be more expensive than its underground cousin, but this is true of practically all prescription medicines against those made by UGL.
Other Proviron pharmaceutical brands may be less expensive, with some costing as little as $0.75 a pill. For obvious reasons, underground grade Proviron is substantially cheaper, with some tablets being offered for as little as $0.50 per pill (25mg).
USA: In the United States, Proviron is classified as a Schedule III drug in the Controlled Substances Act, whereby possession and use of Proviron would be considered a felony. Needless to say, trafficking, importation, and the purchase of Proviron or any anabolic steroid is a criminal act.
UK/England: In the United Kingdom, Proviron falls under Schedule IV, whereby possession and use of Proviron are legal for personal use. Importing Proviron for personal use is also not a felony.
Canada: In Canada, a similar law to that of the UK runs true where it is a Schedule IV drug, whereby possession and use of Proviron is not a felony and is legal.