KPV (Lysine-Proline-Valine)

Lysine-proline-valine (KPV) is a tripeptide found in nature that possesses anti-inflammatory characteristics. It is a -melanocyte-stimulating hormone C-terminal peptide fragment.

KPV's mechanism of action

KPV works as an anti-inflammatory agent inside cells, where it inhibits inflammatory processes. KPV can enter the cell and interact with inflammatory signaling molecules directly. It reaches the cell nucleus and, once there, it can suppress inflammatory chemicals and molecules.

Benefits

• Reduce body weight loss
• Decrease colonic MPO activity
• Decrease histological signs of inflammation
• Decrease pro-inflammatory cytokines mRNA levels
• Attenuate the inflammatory responses of colonic cells

Usage

KPV is used in the treatment of ulcerative colitis