S-23 SARM Guide: Complete Profile, Uses, Dosage, Benefits and Side-effects

Table of Content

  1. General information
  2. What is S-23?
  3. Why Was S23 Created Initially?
  4. Mechanism of Action
  5. Benefits of the S23 SARM
  6. Potential Side Effects Of S23
  7. Dosage
  8. How to take it?
  9. PCT After Taking S23 – Should You Do It?

General information

What is S-23?

S23 is a chemical that belongs to the members of the SARMs (selective androgen receptor modulators). These chemicals were first created to aid cancer patients suffering from muscle atrophy. 
Researchers observed that using these SARMs resulted in fast muscle mass growth and reduced fat in normal and healthy people. 
S23 is one of the lesser-known SARMs, frequently compared to SR9009 Stenabolic. When the two are compared side by side, SR9009 is deemed to be more effective.

Why Was S23 Created Initially?

S23 was initially developed as a to be male Birth control. It is a potent androgen that has shown the potential to lower sperm count. S23 offers additional advantages, such as increasing lean body mass and decreasing fat mass. 
S23 is currently being researched as a possible prevention of pregnancy. Athletes and bodybuilders in the fitness sector have begun to use S-23 to improve their performance and physical attractiveness. S23 is utilized to burn extra body fat during cutting cycles. 

Mechanism of Action

The selective androgen receptor modulator binds with the androgen receptor, demonstrating both anabolic and androgenic action. S23 SARM has anabolic benefits such as enhanced protein synthesis, androgenic effects such as increased bone mineral density and higher libido.  Although the precise processes by which S23 SARM has its effects are unknown, it will likely function via altering the androgen receptor signaling pathway. 

S-23 SARM has been proven in animal experiments to be more effective than testosterone in terms of anabolic effects, making it a prospective option for treating disorders, including muscle wasting and osteoporosis. Human clinical studies are now being conducted to assess the safety and effectiveness of S23 SARM.

Benefits of the S23 SARM

  • Increased Lean Muscle Mass
  • Faster Muscle Growth
  • Accelerate Body Fat Loss
  • Minimal to no water retention
  • Harder muscle aesthetic
  • Prevents muscle wasting.
  • Improved Bone Strength
  • Male Birth Control Pill
  • Female Sexual Motivation

As we'll see shortly, researchers are considering using the S23 SARM as a kind of male birth control because it suppresses sperm production while on it. Still, after you stop taking it, your natural testosterone production and sperm levels return to normal. 
Below is a detailed description of the benefits mentioned above. 

Increased Lean Muscle Mass

It has been shown to improve lean muscle mass in humans. According to researchers, it is more anabolic than testosterone and less androgenic, resulting in enhanced muscle development with fewer negative effects. While further study on humans is needed, findings on rats show that S23 may be a good alternative for anyone trying to lose body fat. S23-treated rats grew considerably greater muscle mass than control rats in one research. According to the researchers, it acts by attaching to androgen receptors, causing an increase in protein synthesis and muscle development.

Faster Muscle Growth 

One of the most important advantages of S23 is increased muscle mass because this SARM was originally developed to treat muscle wasting in cancer patients. It helps in assisting its users in gaining muscular tissue. 
Most individuals who use this SARM report gaining 10-15 pounds of muscle growth with one cycle of S23, but it's not uncommon for people to gain up to 20-25 pounds of muscle mass. 
S23 has been demonstrated in trials to grow muscle dose-dependently and cut off body fat by boosting fat oxidation in the body. While S23 will help you gain muscle, it is not considered a bulking SARM. If bulking up is your primary objective, it is recommended to try Ibutamoren MK 677 instead of S23. 

Body Fat Loss 

The main advantage of S23 is its capacity to assist users in losing weight. It's fairly uncommon for people to lose 10 pounds, 20 pounds, or 30 pounds of fat, depending on the length of the cycle.  S23, like Cardarine (GW-501516), accelerates muscle growth and encourages fat oxidation in the body, allowing it to promote fat loss to such an extent that it is called a cutting SARM. While various contextual factors influence the results, most people respond positively to S23 in general. S23, by increasing your body's metabolism, can lead to not just increased muscular development but also increased fat reduction.

Minimal to no water retention

Users have experienced no bloating or water retention while taking S23, meaning they could keep all their gains even after their S23 cycle ended. As a result, bodybuilders and athletes frequently utilize S23 for cutting.

Harder muscle aesthetic

If preparing for a competition, S23 may help build a tougher, grainier muscular aesthetic because it supports the development of dry, lean muscles.

Prevents muscle wasting

S23 has been reported to assist in avoiding losing muscle mass due to glucocorticoids (glucocorticoids can cause substantial muscle loss when taken long-term). S23 protected the size of fast-twitch (power) and slow-twitch (endurance) muscles against glucocorticoid overuse.

Improved Bone Strength 

Another advantage of S23 is that it promotes bone strength. It accelerates the natural creation of bone-building cells, promoting diverse bone tissue growth.  This is not unexpected, given that many other SARMs have been studied for this purpose, and clinical trials indicate that some SARMs might be utilized to treat osteoporosis.  S23 treatment dramatically enhanced bone density, that are prone to reduced bone mineral density.  S23 considerably enhanced bone mineral density, indicating that it might be a possible therapy option for osteoporosis patients. 

Male Birth Control Pill 

S23 is now being researched as a possible birth control for males. It has been studied and demonstrated to suppress sperm production when on cycle efficiently.  More significantly, after you stop consuming humans, your sperm counts will return to normal, making S23 the ideal birth control for guys. 
Because the half-life of this substance is quite short, continuous dosage is required to maintain stable blood levels and make it a fully effective birth control. But more on dose later. 

Female Sexual Motivation

This study aimed to look into the effects of S-23 on the sexual drive of ovariectomized female rats. S-23 significantly increased sexual drive in all females, with equivalent increases reported at dosages ranging from 0.05 mg/day to 3 mg/kg/day.

Potential Side Effects Of S23

While this SARM is far safer than anabolic steroids, it has side effects too. S23, like many other powerful SARMs, has been related to the following negative side effects. Below are a few side effects that S23 causes.

Testosterone suppression

While S23 mimics the activities of testosterone in your body, it can reduce natural testosterone production to the point that some users have had to supplement with TRT to compensate for the subsequent testosterone deficit. Fortunately, this adverse effect is temporary and may be reversed after your cycle. However, you are strongly advised to utilize PCT to restore natural production as soon as possible. S23 will also lower FSH and LH levels.


S23, on the other hand, might produce greater aggression, so if you have a history of rage difficulties, it is recommended to avoid this

Testicular atrophy

S23 can cause your testicles to shrink.  This is due to S23 inhibiting natural testosterone production rather than raising testosterone. Again, this is only temporary, and you should resume normalcy after your cycle.

Dark urine 

This is hardly the worst negative effect you might experience. However, it is important to be aware that darker urine is a typical occurrence while cycling with this supplement.

NOTE: Your urine color should revert to normal when you're through.

Hair loss

s23 causes hair loss, which is rare for this SARM.

Night Sweats

It's critical to remember that S23 will cause you to get dehydrated throughout the night, so have water available at all times. It causes cramps, migraines, and tiredness.
S23 is thought to produce night sweats because it increases our body's metabolic rate, causing thermogenesis to occur spontaneously. Waking up in a puddle of your sweat when on S23 is not uncommon, and there isn't much you can do about it if you observe this adverse effect.


S-23 is prescribed at 25-50 mg daily for 8-12 weeks. To reduce the chance of adverse effects, start at the low end of the dosage range and gradually increase as tolerated. 

The following is the suggested S23 dosage: 

  • 10mg/day for beginners;
  • 15mg/day for intermediates;
  • 20mg/day for advanced users.

How to take it?

S23 can be administered orally or intravenously. It's better to take it with meals if you take it orally. If you must inject, utilize sterile equipment and techniques.  You may always take bigger doses, but remember that the higher the dosage, the more your hormone levels and other factors will be altered.

PCT After Taking S23 – Should You Do It?

S23 MUST be completed with PCT since it will demolish your natural testosterone levels. (If you do not wish to use a PCT, you will not be required to do so if you use Stena 9009 instead.) As a result, if you want to avoid full testosterone shutdown, you need to include PCT in your cycle. Users recommend Clomid with Nolvadex to assist in restoring your hormone levels quickly while preserving your muscle and power gains. Similarly, they recommend maintaining your PCT cycle to the same length as your S23 cycle. PCT can help you keep up all of your hard work, so you don't have to worry about muscle loss or fat regaining. Rather, it can return your hormones to their original condition.

Read more about SARMS on steroidwiki articles. 

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