GHRP 2 Complete Profile, Usage, Dosage, Pros and Cons

Table of Content:

  1. Introduction to GHRP-2
  2. Molecular Structure of GHRP-2
  3. GHRP-2 vs GHRP-6
  4. Methods of Functioning
  5. Benefits of GHRP-2
  6. Who can use GHRP-2?
  7. Dosage of GHRP-2
  8. The Half-life of GHRP-2
  9. Best Approach to Preserving GHRP-2
  10. Side-effects of GHRP-2

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Introduction to GHRP-2

Formula: C45H55N9O6.

Physical appearance: White powder

Salt Form: Acetate

Solubility: NaCl / Bacteriostatic water

Molecular Mass: 817.9 Dalton

GHRP-2 is a short form for Growth Hormone Releasing Peptide which is also known as Pralmorelin, that stimulates the body to enhance the natural production of growth hormone. It is a synthetically produced, non-glycosylated polypeptide chain that consists of 6 amino acids. GHRP-2 activates Ghrelin Hormone (Hunger Hormone) which is released in small quantities from the brain, pancreas, and small intestines and binds to the growth hormone secretagogue receptor. It encourages significant increases in the body's production of growth hormone while reducing the potential adverse effects of GHRP-6 related to appetite. This peptide doesn’t attach to proteins or glycans.

Molecular Structure of GHRP-2

GHRP-2 vs GHRP-6

GHRP-2 is known as the second generation of GHRP, just behind GHRP-6. But the results of GHRP-2 are far better than those of GHRP-6 because it has very manageable effects as of ghrelin. Some peptides aren't as advisable because of this adverse effect, which is that extremely high ghrelin levels produce severe hunger. Fat consumed by the stimulation of GHRP-2 is stored as energy and burns when one workout.

Because GHRP-2 sustains maximum growth hormone elevations for longer lengths of time than GHRP-6, it is regarded as being significantly superior in terms of growth hormone stimulation. GHRP-2 also has shown an increase in IGF-1 (Insulin-like Growth Factor 1).

Method of Functioning

The very initial thing that GHRP-2 does is intensify the natural growth hormone-releasing signal. This results in a considerable secretion of growth hormone. The next action of GHRP-2 is to suppress Somatostatin, a hormone in the body responsible to reduce its natural growth hormone production. Somatostatin is also known as Growth Hormone Inhibiting Hormone (GHIH). GHRP-2 can enhance growth hormone production by limiting the function of somatostatin, leading to higher levels of natural growth hormone. Moreover, GHRP-2 stimulates Ghrelin, a peptide hormone formed in the gastrointestinal system, which has a profound effect on growth hormone production and appetite. As GHRP-2 aids the body to produce growth hormone, it does not turn off the natural production of growth hormone.

The comparative advantage of consuming this peptide is that instead of increasing continuously, GHRP-2 stimulates the secretion of growth hormone in a way that closely matches natural release patterns. The proper production, secretion, and usage of GHRP-2 are maintained.

Additionally, it inhibits somatostatin's activity, a hormone that controls growth hormone secretion. Because of these effects, GHRP-2 is an excellent choice for raising endogenous growth hormone levels.

Benefits of GHRP-2

There is a long list of advantages of using GHRP2, which are mentioned below:

  • Increased muscle mass
  • Decreased body fat
  • Stimulates flexibility
  • Improves joint health
  • Quick recovery from training or injuries
  • Improves sleep cycle
  • Promotes anti-aging
  • Assist in a major increase in strength and endurance
  • Heals from surgery
  • Speed up muscle tissue growth
  • Increase in muscle mass
  • Acts as a mood stabilizer
  • Enhance productivity
  • Enhanced bone mineralization
  • Increase in calcium retention
  • Increase of hypothalamus stimulation, which promotes sexual drive.

Other than these benefits, GHRP-2 when consumed at higher levels can also boost the production of IGF-1. It creates muscle-building effects in the body. This leads to enhancing lean body composition while accelerating muscle tissue and reducing extra fat from the body. The overall immune system is affected positively by GHRP-2 which results in comprehensive wellness.

Who can use GHRP-2

As there are several different functions of GHRP-2, it can help bodybuilders, runners, boxers, and athletes as well to achieve their goals. Additionally, women can also use this peptide therapy, as it exhibits anti-aging properties. With the usage of this peptide, physical capability, aging-related decrease, and athletic performance can all significantly improve, so whoever you are, if your goal is associated with these characteristics then do not hesitate to use it.

Dosage of GHRP-2

This peptide is injected subcutaneously into the fatty area just under the skin of the human body. Always be sure you use a clean, sterile syringe before giving GHRP-2. It is recommended to insert the needle into the abdomen area or in the stomach as shown in the image below.

Other than the injection, it is also available in oral form as well as intranasal.

  • 15ml Nasal Spray contains 5mg
  • 30ml Nasal Spray contains 10mg

The images of the nasal spray of GHRP-2 are attached below for your reference.

Since GHRP-2 is delivered as a lyophilized powder, so the initial step is to reconstitute it. A lyophilized powder is converted into a liquid solution through the process of reconstitution, which involves adding a diluent. The suggested diluents include sterile water solution, bacteriostatic water, and sodium chloride (NaCl), 0,9% to prepare the injection.

  • Dosage Level:150mcg -300mcg (0.15mg - 0.3mg)
  • Dosage Frequency:1 to 3 times daily

There are different levels of dosage patterns for different goals. As for strength gain or improved performance, a recommended dosage of 300 mcg/0.3mg is consumed thrice a day. For anti-aging use, it is advisable to consume 150 mcg/0.15mg once before bed regularly. It is advised to refrain from eating for at least an hour before and an hour after injecting GHRP-2 for the best outcomes.

The Half-life of GHRP-2

Its half-life is brief, with peaks in concentration occurring 15 to 60 minutes after administrating and lasting for a short period of time.

Best Approach to Preserving GHRP-2

The storage options should be chosen very carefully to let the peptide or any other medicine last longer and remain safer to be used. The advisable practice is to store GHRP-2 (lyophilized powder) in a cool and dry area. Another option to store GHRP-2 is to place it in the refrigerator but keep in mind that it isn't accessible to children.

The accurate temperature of storing GHRP-2 is approximately 4 degrees Celsius/39 degrees Fahrenheit. Other than GHRP-2, several peptides in the solution require the same temperature to last for 3 weeks. At a storage temperature of -20 degree Celsius, peptides are stable for about 3 months.

It is studied that short-term temperature changes don’t affect the efficiency of peptides or their quality during their transportation.

Lyophilized peptides should be permitted to warm to room temperature before the reconstitution. The expiry date of reconstituted peptides is very short. It is advisable for reconstituted peptides to be stored at 2-to-8 degrees Celsius temperature. At this temperature, the majority of peptides in the solution can be stable for up to three weeks. Peptides in solution can remain stable for three months at a storage temperature of -20 °C. Meanwhile, be careful to avoid repeated freezing and thawing to keep the drug safe and effective.

Side Effects of GHRP-2

Now you must be wondering if you start using GHRP-2 for your needs then what about the after-effects? Worry not because this peptide has extremely mild side effects. The common effects that happen to its users are listed below:

  • A modest increase in appetite may occur as a result of ghrelin's increased activity.
  • Tiredness and lethargy are felt which may be reduced with administration before bed.
  • Excessive usage of GHRP-2 can lead to water retention and tingling or numbness in the hands and feet.
  • It is possible for GHRP-2 to cause gyno.
  • Irritation can occur on the skin where the injection needle is inserted.
  • Decreased insulin sensitivity which can result in type 2 diabetes
  • High level of cortisol and prolactin production from GHRP-2 is noticed.

There are no further adverse side effects that would be androgenic, cardiovascular, or connected to the lowering of testosterone. After reading the list of extremely small adverse effects, you must say "YES!" to begin the use of GHRP-2 for your requirements.

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