Andarine (S-4) : Complete Profile, Dosage, Results, and Other Relevant Information

Table of Content

  1. What Is Andarine S4?
  2. Structure
  3. Mechanism of Action
  4. Dosage
  5. Uses & Effectiveness
  6. Benefits of Andarine
  7. Side Effects of Andarine
  8. S-4 Dosing for cutting
  9. Is it legal to consume andarine?
  10. The half-life of Andarine S-4


What Is Andarine S4?

Andarine is a selective androgen receptor modulator (SARM) designed to treat osteoporosis and muscle wasting. It is also known as S-4, S-40503, or 8. It also aids in the prevention of muscle waste and the development of muscular mass. SARMs (selective androgen receptor modulators) are medicines that bind to the androgen receptor (AR), the hormone testosterone's primary site of action. S4 SARM differs from other SARMs in that it is anabolic and stronger, with fewer negative effects (since it interacts selectively rather than with every androgen receptor it meets). Andarine was formerly considered the "ideal" SARM due to its excellent oral bioavailability and muscle- and bone-building properties.


Mechanism of Action

It functions and performs similarly to anabolic steroids but has fewer side effects. It is not just fast-acting, resulting in muscular increases in a shorter period, but also an extremely powerful substance. It stimulates lean muscle mass growth and increases strength by binding to receptors in your muscle and bone tissues.
Andarine works by targeting androgen receptors (ARs) on a tissue-selective basis. It mainly binds ARs in the muscle and bone tissue, sparing the reproductive organs. This distinguishes it from Testosterone and anabolic steroids, whose effects aren't as limited.
When andarine attaches to these receptors, it signals the body's muscles and bones to develop. Andarine, unlike steroids, has fewer negative effects in other body regions.


There is no safe dose for this treatment because it has not undergone adequate clinical studies or has been approved by any regulatory agency.  The typical dosage range is 50 to 75 mg daily (split into three doses with meals). Some people begin with lesser dosages of 25 to 50 mg per day. Andarine is often cycled. Because this medicine is not authorized, the quality and authenticity of the product are frequently questioned. 

Uses & Effectiveness

  • It has several applications in the realm of fitness and muscular building.
  • It is used for sarcopenia, which decreases muscular mass as we age.
  • Athletic ability.
  • Prostate enlargement (benign prostatic hyperplasia, or BPH).
  • Involuntary weight loss in critically unwell patients (cachexia or wasting syndrome).
  • Osteoporosis.
  • Cancer of the prostate.

Benefits of Andarine

Andarine offers several advantages. The following is a summary of some of its primary consumer advantages. 

Muscle hardening

Andarine can help your muscles get tougher, drier, and more vascular in as little as a week, making it perfect for competition preparation. Users use it by adding it to your stack during your cycle's last 6-8 weeks. It can also provide muscular pumps throughout the day, not just lifting weights.

Increased strength

It also improves strength and endurance within two weeks. With this S4 SARM, several users have reported breaking prior best lift records by week 5 of their cycle.

Fat loss

S4 also assists your body in fat burning. It inhibits the formation of Hormone Sensitive Lipase (HSL), which regulates stored fat metabolism (by signaling your body to use stored fat for energy). Users who took 50mg of S4 for six weeks experienced a fat reduction of up to 7 lbs and increased lean muscle mass.

Muscle mass gain

There are mixed opinions about S4's muscle-building capabilities. However, according to research, Andarine can assist users in achieving decent muscle mass increases during a bulking cycle - even if the Andarine dose is minimal. It also aids in muscle retention during cutting. By the end of an 8-week cycle, users taking 50mg had gained 6-8lb of lean muscle mass. 

No water retention

It also helps to strengthen muscular and bone tissue without creating bloating.

Increase Muscle Mass

According to studies, S4 helps to keep muscles from wasting. S4 enhances muscular development and strength. Andarine raised muscular weight in as much as DHT (dihydrotestosterone).

Increase Bone Strength and Combat Osteoporosis

Andarine boosted the mineral density and strength of the bones. Andarine may be especially effective in osteoporosis since it increases bone density and muscular strength, lowering the incidence of injuries and fractures.

Side Effects of Andarine

Testosterone suppression

Andarine is an unapproved drug with absolute side effects. LH (luteinizing hormone) and FSH (follicle-stimulating hormone) stimulate the synthesis of reproductive hormones in both men and women, and their inhibition may reduce normal estrogen/testosterone levels. Andarine decreased LH and FSH, which were high due to castration.

Damage to the liver, heart attack, and stroke

Andarine may be hazardous. Some persons using andarine have suffered liver damage, heart attacks, and strokes.

Visual issues

The most often reported negative effects are visual issues such as a yellow tint and trouble adapting to night vision. These vanish as the medication is stopped. Side effects are more severe at higher dosages. Some users reported nighttime blindness and a little yellowish tinge to their eyesight.


Some people also report feelings of depression.

S-4 Dosing for cutting

For most people, a 50mg dose plan for 6-8 weeks is suitable for cutting. However, due to the eyesight adverse effects, some prefer to utilize a five-on-two-off strategy, in which S4 is administered for five days followed by a 2-day rest (then this cycle is repeated).

Is it legal to consume andarine?

It is legal to purchase as a research compound. It can only be utilized for laboratory study.

The half-life of Andarine S-4

Andarine S-4 has a four-hour half-life.

Read more about SARMS on steroidwiki articles. 

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