Steroid Profile: Testosterone Enanthate
Table of Contents
Profile Of Testosterone Enanthate
- Structure: 17b-hydroxy-4-androsten-3-one
- Molecular Weight: 412.6112
- Molecular Weight (base): 288.429
- Molecular Weight (ester): 130.1864
- Formula (base): C19 H28 O2
- Formula (ester): C7 H12 O
- Melting Point (base): 155
- Manufacturer: Various
- Effective Dose (Men): 200-1,000mg/week
- Effective Dose (Women): 100 - 400mg/week
- Active life: 8 days
- Detection Time: 3 months
- Anabolic/Androgenic ratio: 100/100
Overview & History of Testosterone Enanthate
It is an injectable compound with a slow rate of release due to the larger Enanthate ester attached to the Testosterone molecule. Testosterone that is un-esterified holds a very short half-life, making its use very inconvenient and impractical (Testosterone suspension is one such Testosterone product that consists of pure un-esterified Testosterone, and does not have an ester bonded to its structure). The Enanthate variant of Testosterone had first been described in the early 1950s when it had landed on the market and experienced increasingly extensive use shortly thereafter.
This was the very first injectable Testosterone ester preparation that provided slower release rates. Prior to the development of Testosterone Enanthate, the most widely utilized forms were either un-esterified Testosterone (Testosterone suspension) or the faster acting Testosterone Propionate, which holds a half-life of approximately 4.5 days, necessitating more frequent injections which can be inconvenient for many.
In the United States, Delatestryl manufactured by Squibb was the very first Testosterone Enanthate product to be marketed, and it is still manufactured and marketed today only under different pharmaceutical manufacturers that have purchased the rights to market that name brand. Ultimately it is the Testoviron brand name that is the most popular and widely utilized Testosterone Enanthate product in the world.
Within the medical realm, Testosterone Enanthate is almost exclusively used for the purpose of treating hypogonadism and andropause (two conditions in which adult males produce inadequate levels of Testosterone endogenously).
In some lesser cases, it is also used as a treatment for delayed puberty in male teenagers and for pubertal stimulation. More rare treatments that Testosterone Enanthate is used in include breast cancer treatment in females. Testosterone Enanthate has also been studied thoroughly in its proposed use as a male birth control treatment.
This suppression of spermatogenesis was shown to remain for as long as Testosterone Enanthate was administered, and slowly returned to normal following termination of use.
Various nations and cultures in Eastern Europe and in the far East, however, have displayed a much more accepting attitude towards its use than in the West.
Chemistry Behind Testosterone Enanthate
Testosterone Enanthate is simply Testosterone with the Enanthate ester bound to the Testosterone chemical structure. Specifically, ‘Enanthate’ is Enanthoic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Enanthoic acid is bonded to the 17-beta hydroxyl group on the Testosterone structure.
Esterified anabolic steroids are more fat-soluble, and release slowly from the injection site – however, this is not the main reason why esters extend the release rate of the anabolic steroid. The primary reason for the augmentation of its half-life and release rate is because once Testosterone Enanthate enters the bloodstream, enzymes work to break the bond between the ester and the hormone, which takes a varying amount of time.
The end result is that the ester is removed from the hormone by enzymes, and what is left is pure Testosterone that is free to do its work in the body. This process of enzymes cleaving off the ester from the Testosterone molecule is what is responsible for the slower release rates.
Testosterone alone with no ester bonded to it possesses a half-life of approximately 2 – 4 hours. When the Enanthate ester is attached to it, creating Testosterone Enanthate, the half-life of Testosterone is now extended to 10 days, providing a slower release and activity of the hormone.
Attaching the Enanthate ester allows for control of the hormone’s active duration and total release time. Once injected, the testosterone does not become active until the ester begins to detach from the hormone. The total detachment does not happen all at once but allows for a slow, steady release of the active hormone into the body.
By its time frame, Testosterone Enanthate carries a half-life of approximately 8 days, which will allow for as little as one injection every 2 weeks in a therapeutic setting. As is with all testosterone hormones, Testosterone Enanthate carries an anabolic rating of 100 and an androgenic rating of 100.
On a functional basis, Testosterone Enanthate is the perfect remedy for treating low testosterone. If you suffer from low testosterone, this simply means your body is no longer producing enough of this primary androgen on its own. As Testosterone Enanthate is simply that, testosterone, it will remedy the low-level condition.
Millions upon millions of men worldwide suffer from some type of low-level androgen deficiency. Women can also suffer from low testosterone and Testosterone Enanthate can treat it.
The symptoms of low testosterone include:
- Loss of Libido (can refer to partial or total loss)
- Erectile Dysfunction (inability to maintain or obtain and erection)
- Loss of Muscle Mass (despite diet & exercise)
- Loss of Strength (despite diet & exercise)
- Increased Body Fat (despite diet & exercise)
- Loss of Mental Clarity
- Decreased Ability to Focus
- Decreased Energy
- Weakened Immune System
In fact, it’s very possible that you could end up suffering from every last symptom on the list. It’s also important to keep in mind if the condition is ignored low testosterone has been linked to contributing to many far more serious conditions such as:
- Alzheimer’s Disease
- Heart Disease
Talk to your doctor about the condition and seek out treatment with compounds like Testosterone Enanthate. As a result, there are five important traits of testosterone that will be greatly enhanced and are imperative to performance enhancement success. Protein represents the primary building block of muscle tissue, where synthesis represents the rate by-which cells build proteins. By supplementing with Testosterone Enanthate, the rate of synthesis is enhanced.
This promotes higher levels of anabolic activity and enhances the body’s ability to recover. By enhancing nitrogen retention, we protect the anabolic atmosphere and to a degree enhance it even more. All lean muscle tissue is comprised of approximately 16% nitrogen and when levels fall this leads to a catabolic (muscle wasting) state.
This will enhance tissue growth abilities and will be imperative when dieting when it comes to protecting lean muscle tissue. Increased Red Blood Cell Count: By increasing our red blood cell count we greatly increase our muscular endurance. Insulin-Like Growth Factor-1 (IGF-1) is a naturally produced protein hormone (peptide class) that is primarily produced by the liver.
This hormone is highly anabolic and affects nearly every cell in the human body. The hormone also plays a strong role on the body’s ability to heal and recover affecting muscle tissue, cartilage, nerves, tendons, ligaments and even our central nervous system among many other areas.
Glucocorticoid hormones are naturally produced steroidal hormones; however, they are not anabolic. In fact, glucocorticoid hormones are catabolic (muscle wasting) as they destroy muscle tissue and promote fat gain. By inhibiting these hormones, we again promote a stronger anabolic atmosphere.
Effects Of Testosterone Enanthate
If you suffer from low testosterone, you should also know that the only thing that will fully remedy the condition is direct testosterone therapy through hormones like Testosterone Enanthate. For the off-season individual, there are very few anabolic steroids that can promote lean tissue growth like Testosterone Enanthate.
The individual will be able to pack on raw size at a significant rate so as long as adequate calories are consumed. High levels of testosterone will enhance the individual’s overall metabolic rate tremendously.
This isn’t a license to eat with no end in sight, you can still gain fat but you should be able to make better use of your calories. In order to lose body fat, we must burn more calories than we consume. You can eat the healthiest food on earth and exercise four hours a day, but if you’re consuming more than you burn you will not lose any fat. The body will take what it needs to meet its energy demands from anywhere it can get it and this can include muscle tissue. By supplementing with Testosterone Enanthate, the pronounced enhancement of anabolic action will protect this lean tissue and ensure we only burn body fat. It will also see our metabolism greatly enhanced so that we burn body fat at a more efficient rate.
High testosterone levels will result in greater muscular endurance. You will also find your overall rate of recovery is greatly improved, which is essential to progress. It is through recovery that we progress.
This makes compounds like Testosterone Enanthate not only invaluable to bodybuilders and recreational gym rats but to athletes as well. Endurance and recovery are two of the key elements to successful athletic performance. As an added bonus, high testosterone levels will increase the individual’s strength.
Side Effects of Testosterone Enanthate
Testosterone Enanthate is an anabolic steroid with a very moderate side effect profile. When considering its benefits in terms of potential gains and strength versus its side effect potential and profile, it can be considered a very reasonable anabolic steroid in this regard.
Testosterone Enanthate’s side effect distribution is generally pretty varied, but what one must understand is that Testosterone Enanthate being a Testosterone compound, is the body’s most natural anabolic hormone.
Testosterone Enanthate side effects include that of estrogenic side effects, which are the most prominent side effects that users and potential users are most concerned about. This results from the fact that Testosterone is a moderately aromatizable anabolic steroid (meaning Testosterone undergoes conversion into Estrogen at a moderate rate in the body), and this is of course proportional to the dose of Testosterone Enanthate used as well.
The resultant side effects of Estrogen conversion can include: water retention and bloating, increases in blood pressure (resultant from water retention), increased fat gain/retention, and potential development of gynecomastia.
Androgenic side effects can include: increased oily skin (sebum secretion), increased acne formation (linked to sebum secretion), bodily and facial hair growth, and the increased risk of experiencing male pattern baldness (MPB) if the individual possesses the genetic predisposition for it.
Being that it is an anabolic steroid, Testosterone Enanthate does exhibit side effects in regards to impairment and/or suppression of the HPTA (Hypothalamic Pituitary Testicular Axis) – in other words, natural endogenous Testosterone production suppression. Testosterone Enanthate side effects also include cardiovascular alterations and side effects, such as temporary alteration of blood cholesterol levels.
Cycles And Usage of Testosterone Enanthate
Medically, Testosterone Enanthate is usually utilized at a prescription dosage of around 250mg administered once every 2 – 4 weeks, depending on the discretion of the physician and the patient’s progress in his TRT therapy.
For the purpose of bodybuilding and performance and physique enhancement, Testosterone Enanthate is usually dosed at around 300 – 500mg per week as a beginner dosage. Intermediate Testosterone Enanthate dosages can run from 500 – 750mg per week, and advanced users are known to utilize upwards of 1,000mg or more per week of Testosterone Enanthate.
Because of its half-life of 7 – 10 days, it is recommended that Testosterone Enanthate’s administration occur at a minimum of once per week, but ideally for optimal performance and results (and minimization of unwanted side effects due to spiking blood plasma levels), it should be administered twice per week with the weekly dosage split evenly between administrations.
How To Buy and Price of Testosterone Enanthate
Testosterone Enanthate is a very popular anabolic steroid that should be quite easy to get by on the anabolic steroid black market. It's also so ubiquitous and easy to make that it should be available for a very low price.
On the market, there are both human-grade pharmaceutical grade and underground lab (UGL) grade testosterone enanthate products. The distinctions are clear, with quality control being the most important factor, and pharmaceutical grade Testosterone Enanthate being more expensive for obvious reasons.
Testosterone Enanthate is available from both internet sources and merchants, as well as conventional in-person transactions (such as 'gym-dealers'). Prices are subject to change. A single 1ml vial of pharmaceutical Testosterone Enanthate containing 250mg/ml (which is about $13 – $15) may be bought for roughly $13 - $15.
Pharmaceutical Testosterone Enanthate can be found for around $13 – $15 for a single 1ml vial containing 250mg/ml (which is usually the standard for pharmaceutical grade glass ampoules). Underground Testosterone Enanthate normally sells for $60 – $90 for a single 10ml vial containing 250mg/ml.