Neo-Ponden (Androisoxazol): A Comprehensive guide

Chemical Composition

Neo-Ponden, also known as androisoxazol, has the following chemical compositions:

• 17-alpha-Methylandrostan(3,2-c)isoxazol-17-beta-ol
• 17-Methyl-5alpha-androstano(3,2-c)isoxazol-17beta-ol
• 17-beta-Hydroxy-17-alpha-methylandrostano(3,2-c)isoxazole

Molecular Weight: 329.47634 [g/mol]

Formula: C21H31NO2

Effective Dose (Men): 15-40 mg/day

Effective Dose (Women): 5-10 mg/day

Anabolic/Androgenic Ratio: 155/22

Description

Neo-Ponden is a type of steroid that comes from another steroid called dihydrotestosterone, which is often shortened to DHT. It's a bit different from regular DHT because it goes through two changes. First, it gets a chemical called c-17alpha alkylation, which helps protect it when it goes through the liver. This means it doesn't break down as easily. Second, it gets an isoxazole group added, which changes a part of its structure, making it less likely to cause certain male-like effects but better at helping muscles grow.

This steroid contains something called androisoxazol, which is a special version of DHT that scientists made in the 1950s and 1960s when they were trying to change how testosterone-based hormones worked.

People like using Neo-Ponden because it helps muscles grow in a way that makes them harder and denser, which is good for athletes who compete or bodybuilders getting ready for a competition. It doesn't cause the body to make more estrogen, a hormone that can lead to female-like effects in men, so it's a safer option for many people. It's a bit like another popular steroid called Winstrol, but some say it's even better for certain types of muscle-building routines.

Structure 

Dosage

Recommended dosage for Neo-Ponden:

• Men: 15-40 mg/day for 6-8 weeks.
• Women: 5-10 mg/day for 4-6 weeks.

Similar to Neo-Ponden  and Anavar, its low androgenicity makes it safe for female use. Neo-Ponden contains a 17-alpha-methyl group to enhance oral bioavailability and an isoxazole group to minimize androgenic side effects while augmenting anabolic activity.
Intended Effects

Goal of Neo Ponden

The main goal of Neo-Ponden was to help people build lean muscle, similar to what happens when the body naturally produces DHT. But the creators also wanted to make sure it didn't cause as many female-like effects in men, which can happen with some steroids. They hoped it would give moderate but good-quality muscle growth and make people stronger without adding too much extra bulk or causing the body to hold onto excess water.

Some people compare its effects to Neo-Ponden and another popular steroid called Anavar. However, these claims haven't been proven through studies with real people yet. So, while some people believe Neo-Ponden can do all these things, there isn't solid evidence to back it up.

Obscurity and Disappearance

Despite initially attracting attention, Neo-Ponden gradually faded into obscurity after a few years. This was mainly because other oral steroids proved to be more effective at improving physical appearance. As a result, Neo-Ponden became extremely rare and is not used by humans or animals. Instead, it's mostly seen as something interesting from the past rather than a practical choice for people who use steroids.

In summary, Neo-Ponden didn't reach to its expected potential as an oral steroid. As our understanding of steroids has grown and better options have become available, Neo-Ponden has been left behind and forgotten.

Indications/Purpose & Side Effects

Medical Uses: Neo-Ponden is prescribed to address specific medical conditions such as angioedema, a condition characterized by rapid swelling beneath the skin's surface, and anemia, which involves a deficiency in red blood cells. Neo-Ponden stimulates the process of erythropoiesis, which refers to the production of red blood cells, thereby helping to alleviate symptoms associated with anemia. Moreover, it aids in increasing bone density, making it a valuable treatment option for osteoporosis, a condition characterized by weakened bones prone to fractures. In veterinary medicine, Neo-Ponden is utilized to enhance muscle growth, increase production, and improve bone density in animals, particularly in livestock.
Side Effects: Despite its therapeutic benefits, Neo-Ponden, like other anabolic steroids, can induce various side effects, including:

1. Hepatotoxicity: Prolonged or excessive use of Neo-Ponden may potentially damage the liver, leading to hepatotoxicity. This risk is particularly heightened when Neo-Ponden is taken in high doses or over an extended period.
2. Cardiovascular Issues: Neo-Ponden has the potential to negatively impact cholesterol levels, thereby increasing the risk of cardiovascular problems such as atherosclerosis (hardening and narrowing of arteries) and heart disease. Elevated levels of LDL cholesterol (often referred to as "bad" cholesterol) and decreased levels of HDL cholesterol (considered "good" cholesterol) are commonly observed with steroid use.
3. Androgenic Effects: Neo-Ponden can trigger androgenic side effects, which are manifestations typically associated with male characteristics. These may include acne, increased facial or body hair growth, and male-pattern baldness, especially in individuals genetically predisposed to hair loss. In women, Neo-Ponden may lead to virilization, a condition characterized by the development of masculine traits such as deepening of the voice and enlargement of the clitoris.
4. Suppression of Natural Testosterone Production: The use of Neo-Ponden can suppress the body's natural production of testosterone, a hormone crucial for various bodily functions, including libido, mood regulation, and muscle maintenance. As a result, individuals using Neo-Ponden may experience symptoms of low testosterone levels, such as decreased libido, fatigue, and mood changes. This suppression of endogenous testosterone production can persist even after discontinuing Neo-Ponden use, necessitating post-cycle therapy (PCT) to restore normal hormone levels.

It's essential for individuals considering Neo-Ponden therapy to weigh the potential benefits against these potential side effects and to consult with healthcare professionals for guidance on safe and appropriate use.

Conclusion

While Neo-Ponden offers benefits in certain medical conditions and sports performance enhancement, its use must be carefully considered due to the potential for adverse effects. One should stick to recommended dosages and duration of use to minimize the risk of complications.

References

1. Steroid.com. Available at: https://www.steroid.com/Neo-Ponden.php (Accessed: 16 March 2024).
2. Mullen, C., Whalley, B. J., Schifano, F. and Baker, J. S. (2020) British Journal of Pharmacology, 177(10), pp. 2180–2198. doi: 10.1111/bph.14995.
3. Revisiting Neo-Ponden (Androisoxazol): The Obscure Oral Steroid (2023) Steroids Online USA. Available at: https://steroidsonlineusa.com/neo-ponden-androisoxazol/ (Accessed: 16 March 2024).
4. Androisoxazole (no date) National Center for Biotechnology Information. PubChem Compound Database. U.S. National Library of Medicine. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Androisoxazole (Accessed: 16 March 2024).
5. Androisoxazole (2024) DBpedia. Available at: https://dbpedia.org/page/Androisoxazole (Accessed: 16 March 2024).