Palmitoylethanolamide (PEA) – With Levagen Capsules Complete Guide: Dosage, Benefits, Side Effects and Other Relevant Details

Palmitoylethanolamide (PEA) – With Levagen Capsules



"I also suffered from poor sleep and was diagnosed with a form of insomnia a year ago. Using the Levagen pre-bed has improved that significantly and I dream most nights now, whereas before I never did"-  Gloucester Rugby Player.


Palmitoylethanolamide (PEA) – The description

Palmitoylethanolamide (PEA) is a fat-derived natural molecule. It is found in foods such as egg yolks and peanuts, and our bodies also create it. Levagen, a kind of PEA, is an amino acid the body naturally produces. Levagen has anti-inflammatory qualities, which means it can help decrease swelling and relieve long-term discomfort. Levagen is very well absorbed by the body, allowing you to yield the maximum advantages with just one capsule, which generally contains 600mg. When we are injured or anxious, our bodies produce PEA. It's as though our bodies are shouting,

"Hey, we need some help here!" 

I used this phrase to emphasize the significance of PEA within our body.


Palmitoylethanolamide (PEA) – the structure


Big Job of PEA?

Palmitoylethanolamide (PEA) – The natural painkiller

PEA plays a significant role in lowering inflammation, which occurs when areas of our bodies become bloated and uncomfortable. Because of its high absorption, Levagen can effectively reduce inflammation and discomfort. When we become older, or our bodies are under a lot of stress, the quantity of PEA we naturally produce decreases. That is when we may want the assistance of a supplement such as Levagen.

PEA treats many pain problems, including fibromyalgia, osteoarthritis, and even multiple sclerosis and carpal tunnel syndrome. Some individuals believe it can assist with autism, although not all of these claims have been proven scientifically.

Let's explain it through our childhood experiences. When we're kids, our bodies have enough PEA to absorb bumps and falls without feeling too much. However, our bodies may stop producing as much PEA as we age. This is where something like Levagen can come into use.

Some people have discovered that Levagen improves their sleep and refreshes them. It has also been linked to healthier joints and speedier injury recovery. Remember, if you want to test Levagen or any supplement, you should first consult with a healthcare expert.

The Importance of PEA (Palmitoylethanolamide)

Vial containing Palmitoylethanolamide (PEA)

PEA, or Palmitoylethanolamide, is a fatty acid that occurs naturally in human bodies. It is something we make when we are injured or stressed. PEA may be found in foods such as eggs and peanuts, but our systems also produce it as needed. Furthermore, it is already present in our tissues, making it extremely safe and useful.

Now, here's the cool part: 

Palmitoylethanolamide (PEA) has several beneficial effects on human health. PEA is well-known for its anti-inflammatory qualities, effectively reducing physical swelling and promoting comfort. It also acts as a pain reliever, increasing our comfort during times of distress. However, the benefits of PEA go beyond these capacities, as it also helps to protect our neurological system and brain health.

But here's the tricky bit: 

When we are injured, our PEA levels decrease. That can happen as we age when we are anxious, or even when we exercise often. So, we may need to take a supplement to restore our PEA levels to normal and maintain feeling happy. This is where PEA pills come in. They assist us in restoring our PEA levels and keeping everything functioning correctly.

Levagen: A PEA with Superior Absorption

Vial containing Palmitoylethanolamide (PEA)

Levagen is a kind of PEA (Palmitoylethanolamide) that has been thoroughly researched in clinical trials. What distinguishes Levagen is its capacity to alleviate discomfort and increase our general sense of well-being. This component is not only practical, but it also has several significant advantages:

  1. Non-GMO and Gluten-Free: Levagen is free of genetically modified organisms (GMOs) and gluten. This implies it's created without any changes to its original genetic composition, and it's suitable for people who are gluten intolerant.
  2. Allergen-Free Formulation: Levagen is allergen-free. As a result, it is less likely to produce allergic responses in persons allergic to common allergens.
  3. Not a WADA-Banned chemicals: Levagen does not include any WADA (World Anti-Doping Agency)-banned chemicals. Athletes and sports enthusiasts may utilize it with confidence.

Half-Life of PEA

The half-life of palmitoylethanolamide (PEA) is approximately 25 minutes. The half-life of a substance is the amount of time it takes for half of it to be removed from the body. In the case of PEA, this implies it does not remain in the body for a lengthy amount of time. This feature can determine how frequently it must be taken to sustain its benefits throughout the day.
So, adhering to the suggested usage instructions and seeking advice from a healthcare expert will help you get the most out of this supplement while assuring your safety and well-being. Furthermore, studying PEA's half-life gives insight into its length of activity within the body.

Mechanism of action

Mechanism of action of Palmitoylethanolamide (PEA)

PEA (Palmitoylethanolamide) is a pain reliever and anti-inflammatory agent through several mechanisms. It hinders the release of substances from mast cells that cause inflammation, regulates enzymes like COX-2, and prevents specific inflammatory processes. It also lessens reperfusion injury and the harm caused by shock, probably via the PPAR-alpha pathway. PEA activates receptors, PPAR-alpha and TRPV1, which help control pain and inflammation. This multifaceted action results in reduced markers of reperfusion injury and inflammation.

It can lower inflammation by activating PPAR Alpha, a protein that regulates energy and inflammation in the body. PEA may reduce the quantities of toxic chemicals that promote inflammation in this way. PEA also benefits the body by increasing the effectiveness of another natural chemical, anandamide. Anandamide is helpful for pain alleviation and relaxation. PEA accomplishes this by inhibiting the action of an enzyme called FAAH, which degrades anandamide. Furthermore, PEA interacts with a receptor in the digestive system called GPR119. This interaction may impact how the body regulates things like hunger and blood sugar.

Overall, PEA effects have the ability to lower inflammation, enhance pain management, and affect metabolic processes. Researchers are still learning about how PEA works and its potential health advantages.

Potential health benefits of Palmitoylethanolamide (PEA)

Benefits of Palmitoylethanolamide (PEA)

 Palmitoylethanolamide (PEA) is a fatty acid the body produces in reaction to trauma. It has several possible health benefits:

  1. Pain Relief: PEA has shown tremendous promise in treating chronic and severe pain. It might benefit from endometriosis-related pelvic pain, sciatica, carpal tunnel syndrome, knee osteoarthritis, cancer-related pain, post-surgical pain, and fibromyalgia-related muscular pain. Notably, there have been no reports of negative effects from PEA.
  2. Joint Health: PEA can help with joint health, making it useful for people with joint pain or stiffness.
  3. Neuroprotection: PEA can potentially improve recovery and cognitive function following acute ischemic strokes. It also has neuroprotective qualities, which might be useful in neurodegenerative diseases like Alzheimer's.
  4. Glaucoma Treatment: Studies show that PEA can successfully lower intraocular pressure, a vital component in glaucoma, with no side effects.
  5. Depression Support: When used in conjunction with other therapies, PEA can be an adjuvant therapy for major depressive disorder, reducing depressed symptoms.
  6. Multiple Sclerosis: Preliminary findings suggest that adding PEA to standard multiple sclerosis therapy may lessen side effects, relieve pain, and improve quality of life in people with quickly developing MS.
  7. Sleep Aid: PEA may assist in shortening sleep onset time and enhance sleep quality, especially in people with sleep pattern problems.

Levagen is a kind of PEA known for its anti-inflammatory activities. 

  1. Improve Exercise Performance: Levagen has been linked with increased exercise performance by lowering lactate levels, allowing for higher-intensity exercise and perhaps more excellent physical performance.
  2. Increase Absorption: Levagen has twice the absorption rate of conventional forms of PEA, making it more effective.

In summary, PEA and its particular form, Levagen, may provide a variety of possible health advantages, including pain reduction, joint support, neuroprotection, glaucoma therapy, depression support, multiple sclerosis management, and sleep enhancement. Levagen is famous for its ability to improve workout performance. Always with a healthcare practitioner before beginning any new supplement regimen to confirm it is appropriate for your individual health objectives.

Are There Any Side Effects or Safety Issues?

Side effects of Palmitoylethanolamide (PEA)

PEA pills do not appear to have significant adverse effects when taken for up to 3 months. Some people, however, may develop nausea, stomach distress, and diarrhoea. There hasn't been enough clinical research to determine whether using PEA for more than three months is safe. 
PEA appears to have no harmful interactions with other medications and generates little to no adverse effects. 

Other potential adverse effects of PEA supplementation include:

  • Migraines
  • Tiredness

PEA may cause allergic responses in certain people in rare situations; if you see any indications of an allergic reaction, such as hives, rash, or trouble breathing, cease taking PEA immediately and seek medical treatment. 

Uses & Effectiveness

Palmitoylethanolamide (PEA)

PEA has proved successful in various areas, including:

  • Osteoarthritis: PEA has been shown to relieve pain and enhance function in people with osteoarthritis when taken orally.
  • Chronic Pain: When taken orally, PEA has shown promise in relieving chronic pain caused by various factors.

However, PEA may not be beneficial in all cases. It appears to be ineffective for relieving pain or spasticity in those who have had spinal cord injuries.
While there is interest in exploring PEA for other purposes, there is currently insufficient reliable information to determine its effectiveness in those areas.

Special Precautions and Warnings

  • Short-Term Use: When taken orally, PEA is typically considered safe for up to three months. Although most people handle it well, others may develop nausea. Little data is available on the safety of long-term usage beyond three months.
  • Skin Application: PEA may be safe to apply to the skin for up to 28 days.
  • Pregnancy and nursing: There is insufficient credible data to assess the safety of using PEA during pregnancy or nursing. It is advised to avoid using it during these times as a precaution.
  • Children: Taking PEA by mouth for up to three months is potentially safe for youngsters aged four to seventeen.  However, it's crucial to consult with a healthcare professional before giving any supplements to children, especially for an extended period.


Palmitoylethanolamide (PEA) Dosage

Adults typically take 300-1200 mg of PEA orally daily for 2-12 weeks. It is most often used in children at dosages of 600 mg by mouth daily for up to 3 months. PEA is also found in lotions, creams, and eye drops. Speak with a healthcare provider to determine what product and dose might be best for a specific condition.

Levagen Formulations

Levagen comes in a variety of formulations, making it simple to find one that meets your interests and lifestyle:

  • Effervescent: Effervescent pills that dissolve in water to produce a tasty and easy-to-drink beverage.
  • Powders: Simple powders that may be blended with water or other beverages to create a personalized experience.
  • Gels: Topical gel compositions that provide tailored relief to certain body parts.
  • Functional Beverages: Beverages supplemented with Levagen to add a delightful and functional touch to your everyday beverages.
  • Capsules: Traditional capsules provide a quick and easy method to include Levagen into your daily routine.
  • Tablets: These are easy-to-swallow tablets that are ideal for people who want a no-fuss choice
  • Gummies: Chewable gummies make it easy to acquire your daily dosage of Levagen

Why Choose Levagen?


There are several compelling reasons to consider Levagen for your health and wellness needs:

  • Low Dose: Levagen provides powerful advantages at a low dose, ensuring you achieve the desired outcomes without overdosing.
  • Quick acting: It acts swiftly, allowing you to reap the advantages sooner.
  • Clinically Researched and Proven Benefits: Levagen has completed a clinical study, demonstrating its efficacy and safety.
  • Economical: It provides cost-effective solutions for various health and wellness goals.
  • Creative Beyond Capsules and Tablets: Levagen offers creative choices beyond typical capsules and tablets, appealing to various tastes.
  • Informed-Ingredient Certified by LGC:  Knowledgeable-Ingredient LGC accreditation assures that every batch of Levagen is extensively tested for the absence of WADA-banned chemicals, providing athletes and active persons with peace of mind.

Whether you prefer a fast-dissolving effervescent tablet, a tasty gummy, or a classic capsule, Levagen has a variety of alternatives to suit your needs. Its established advantages, low-dose efficacy, and dedication to safety make it an appealing option for people looking for a dependable supplement for various health goals. Before incorporating any new supplement into your regimen, always talk with a healthcare practitioner.


Vial containing Levagen

The active component Palmitoylethanolamide (PEA) is included in Levagen at a dosage of 300mg per capsule. This natural chemical is present in various tissues throughout the body and has received attention for its possible health advantages, prompting its usage as a dietary supplement. Levagen also contains additional substances that help build the capsule and maintain its structural integrity. These extra components frequently include cellulose, utilized for the capsule material, and magnesium stearate, frequently used as a flow agent or lubricant in the production process.

In conclusion, Levagen contains Palmitoylethanolamide (PEA) and has been substantiated by clinical trials proving its ability to benefit different areas of health, ranging from joint comfort to sleep quality and exercise performance. This natural substance is a potential option for people looking to improve their general well-being. Consult a healthcare expert before incorporating any new supplement into your regular routine.

Recommended Usage and Safety Considerations

Safety Considerations of Palmitoylethanolamide (PEA)

The suggested dosage for this supplement is straightforward: take one capsule up to two times per day. As a result, you can take one capsule in the morning and another later in the day as needed. However, it is critical to follow the manufacturer's dosage guidelines or the advice of your healthcare expert. Following these directions ensures that the product is used safely and effectively.

It's a good idea to talk with a healthcare expert before starting any new supplement program. This is especially crucial if you have any underlying medical issues or are on any other drugs. Consulting with a healthcare expert helps ensure no potential interactions or adverse effects could impact your well-being.


Vial containing Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) is a fatty acid the body produces in reaction to damage or stress. It may also be present in some foods, such as eggs and peanuts, but our systems produce it independently as required. PEA is essential in lowering inflammation and relieving pain. The body's natural synthesis of PEA might diminish as we age or face increasing stress, making supplements like Levagen useful in restoring PEA levels.

In the form of Levagen, PEA is well-known for its anti-inflammatory qualities, which make it helpful in lowering swelling and chronic pain. Levagen is highly absorbable. Therefore, a single capsule (usually 600mg) gives the whole spectrum of effects. People have claimed Levagen improved their sleep, maintained joint health, and aided injury rehabilitation. While specific possible PEA applications, such as autism, are being investigated, not all have suitable scientific proof.

Levagen is non-GMO, gluten-free, allergen-free, and without ingredients prohibited by the World Anti-Doping Agency (WADA). It comes in various forms, from effervescent tablets to classic capsules, making it flexible to individual tastes and needs. PEA inhibits inflammation by activating particular proteins and enzymes such as PPAR Alpha and FAAH. PEA may boost the effectiveness of the natural component anandamide, which aids in pain reduction and relaxation. Furthermore, it interacts with GPR119 receptors, which may influence metabolic processes.

PEA pills have demonstrated little harmful effects when taken for up to three months, with infrequent complaints of nausea, stomach distress, and diarrhea. There is little information available on long-term usage. PEA has not been shown to interact negatively with other medicines, making it a generally safe alternative. However, it is essential to know the likelihood of headaches, exhaustion, and uncommon allergic responses. PEA has been shown to be beneficial in treating osteoarthritis and chronic pain. Levagen is a kind of PEA validated by clinical research and comes in various forms to suit different needs. It is a cost-effective option for a variety of health and wellness aims.


  1. Clayton, P., Hill, M., Bogoda, N., Subah, S. and Venkatesh, R., 2021. Palmitoylethanolamide: a natural compound for health management. International Journal of Molecular Sciences22(10), p.5305.
  2. Briskey et al., 2022. Efficacy of Palmitoylethanolamide (Levagen+ TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial. Food and Nutrition Sciences13(7), pp.690-701.
  3. Accurate Education - Palmitoylethanolamide (PEA) - Accurate Clinic. (n.d.). Accurate Clinic.
  4. Rao, A., Skinner, R. and Briskey, D., 2023. The Efficacy of Palmitoylethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection—A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients15(20), p.4453.
  5. Rao, A., Ebelt, P., Mallard, A. and Briskey, D., 2021. Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study. Sleep Science and Practice5(1), pp.1-8.

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