Steroid Profile: Winstrol (Stanozolol)
Table of Contents
OVERVIEW AND HISTORY OF WINSTROL/STANOZOLOL
Winstrol is the trade name for an anabolic steroid known as Stanozolol. It is available in both oral and injectable formats, and it sits on the third-place pedestal among the top 3 anabolic steroids most widely used and most popular among bodybuilders and athletes. Medically it compels many uses in terms of performance.
A long-standing favorite among athletes and bodybuilders. It’s a potent cutting steroid and probably one of the preferred choices for the sporting athlete. It’s, furthermore, a decent choice for many women although there are better choices. It is not effective in mass gain. Stanozolol is often referred to as a “Cutting Steroid” and again it’s an essential steroid to serve this purpose.
You however have to diet if you want to cut up and need to diet hard, but the results at the end will be far more pleasing as it gives a chiseled look, with Stanozolol in the mix. Stanozolol has equally sustained a significant amount of success in the medical community and is still used fairly regularly today. As with many anabolic steroids, Stanozolol is used to treat muscle wasting diseases, burn victims, overexposure to corticosteroids, and osteoporosis.
It has also been utilized to aid in healing bone fractures and has indeed been successfully used in obesity treatment when hormone imbalances exist. Specific forms of breast cancer, treating angioedema and even certain forms of delayed growth treatment in children have all proven successful.
Unlike many anabolic steroids in the U.S., Stanozolol has never lost its FDA approval. Stanozolol is probably most famous and well-known for its alleged use by Canadian Olympic sprinter Ben Johnson in the 1988 Seoul Summer Olympic games where he tested positive for it.
However, its origins began in 1959 when its details were first released to the medical and scientific community. It was Winthrop Laboratories in the UK that marketed Stanozolol on the prescription drug market, and Sterling in the USA ended up buying the patent in 1961 for the US market where it was branded as Winstrol.
CHEMICAL PROPERTIES WINSTROL/STANOZOLOL
Winstrol (AKA Stanozolol)
Chemical Name: 17β-Hydroxy-17-methyl-5alpha-androstano[3,2-c] pyrazole
Molecular Weight: 328.49 g/mol
Original Manufacturer: Winthrop Laboratories
Half Life: 9 hours (oral), 24 hours (injectable)
Detection Time: 2 months
Anabolic Rating: 320
Androgenic Rating: 30
Stanozolol is a dihydrotestosterone (DHT) based anabolic steroid. Idiosyncratically, Stanozolol remains a structurally altered form of the DHT hormone, two specific changes to DHT that give us Stanozolol.
The first modification represents the addition of an attached pyrazole group at the A-ring in place of the 3-keto group. This makes Stanozolol a heterocyclic steroid. The second change represents the addition of a methyl group. This change takes place at the 17th carbon position and puts Stanozolol into the 17-alpha alkylated (C17-aa) category.
The structural changes made to DHT that give us Stanozolol reduces the hormone’s androgenicity dramatically and considerably increase its anabolic activity. Stanozolol carries an Anabolic Rating of 320 and an Androgenic Rating of 20 and real-life use will match. Up to, these structural ratings very well. This Pyrazole group, which is a functional group, is indeed responsible for Winstrol’s stronger binding affinity for the androgen receptor in muscle tissue.
As a DHT-derivative with modifications that separate its distinction from DHT, Winstrol is active in muscle tissue to a more substantial degree than DHT itself. Regrettably, DHT is rendered inactive almost immediately by two enzymes upon its entrance into muscle tissue. Winstrol’s modifications allow it to effectively eliminate this problem.
All anabolic steroids that belong to the family of DHT-derivatives such as Winstrol, Anavar, Primobolan, Masteron, and several others, contain modifications to their chemical structures that grant them significant activity and effectiveness within muscle tissue, where DHT itself unmodified would never survive metabolism there.
The Pyrazole structure also grants Winstrol a significant shift in its anabolic and androgenic strengths to favor more of a stronger anabolic strength while greatly reducing its androgenic strength. This is what grants Winstrol an incredibly strong disassociation of anabolic to androgenic effects.
Winstrol equally possesses a methyl group attached to the 17th carbon known as C17 Alpha Alkylation, which is the chemical structural modification that allows the anabolic steroid to survive the first pass through the liver when ingested orally and allows the anabolic steroid to become further resistant to hepatic metabolism.
Stanozolol can significantly reduce Sex-Hormone-Binding-Globulin. SHBG is one of the primary factors that determine how much testosterone in the body is free or bound; higher SHBG means less free testosterone, which represents our active and usable testosterone.
Equally important for the steroid user is that other steroids that may be used are more effective when SHBG is lower. Winstrol has also been demonstrated to not merely prevent SHBG from binding with other anabolic steroids, but it has also demonstrated strong suppression of SHBG production in the body. Stanzol increases the rate of protein synthesis. Protein synthesis is the rate at which cells build proteins, the building block of muscle tissue.
Our muscle tissue is made up of about 16-percent nitrogen and when you have more elevated levels that aren’t retained, which will lead to a muscle-wasting state, otherwise known as catabolism. Elevated levels of nitrogen retention mean that we can build a lot more muscle and ward off hormones that eat into lean muscle tissue. Red blood cells are what carries our oxygen through our blood.
With Stanozolol, you’ll have an increase in red blood cells resulting in tremendously greater oxygen, and that will ensure there is enhanced muscular endurance. Glucocorticoids (stress hormones) often referred to as muscle wasting hormones (cortisol is the most well-known.) promote fat gain and muscle loss.
Stanozolol inhibits glucocorticoids. It will not expel all from your body, and you do need some for-heart reasons, but too much can be problematic. The reduction in glucocorticoids by Stanozolol is not as significant as many other anabolic steroids, but it’s, however, a trait the steroid possesses.
EFFECTS OF WINSTROL/STANOZOLOL
To some modest antagonistic effects on the Progesterone receptor, it has been found that Winstrol also possesses a low affinity for Glucocorticoid-binding site interactions, as well as independent activity of Androgen receptors, Progesterone receptors, and Glucocorticoid receptors. Winstrol has not been found to sustain any notable Progestogenic activity in the body as well.
Winstrol exhibits a longer half-life as a result of its structural modifications, enabling the injectable format of Winstrol to possess a half-life of approximately 24 hours and 9 hours for the oral preparation of Winstrol. About Testosterone, Winstrol holds an androgenic strength rating of 30 with an anabolic strength rating of 320, which is quite significant considering this means Winstrol is vaguely over three times the anabolic strength of Testosterone. Percentage-wise, it could be described that Winstrol is 320% more anabolic than Testosterone, and it is 30% less androgenic than Testosterone.
A significant fact that must be reminded to the reader is the fact that both the injectable and oral preparations of Winstrol possess the exact same chemical structure. This is precisely true when users are training very hard. Most bodybuilders and some athletes will stack Nandrolone with Stanozolol to address the problem of achy joints during this period of time.
SIDE EFFECTS OF WINSTROL/STANOZOLOL
Winstrol usage comes with many side effects and negative reactions if it is not utilized properly. Many of the possible side effects, particularly the severity will revolve around genetic response. Some people respond better to certain things than others. This is a genetic fact of life that holds true with Stanozolol and truly anything we impose into our body steroid or not.
Stanozolol does not aromatize and is not a progestin. Estrogenic side effects like gynecomastia and water retention are impossible with this anabolic steroid. Although Winstrol does possess a weaker androgenic strength rating than Testosterone does, androgenic side effects are still a potential risk, though much lower, and may barely affect users significantly if they are especially sensitive to androgens. Androgenic side effects can include increased oily skin and acne, hair growth on the body, MPB (male pattern baldness), and BPH (Benign Prostatic Hypertrophy).
The use of a 5-alpha reductase (5AR) inhibitor, such as Finasteride, Dutasteride, Proscar, or Propecia will be completely ineffective here, as Winstrol does not convert into DHT. The androgenic side effects of Stanozolol can equally affect women in terms of virilization symptoms.
Virilization symptoms refer to a deepening of the vocal cords, body hair growth, and clitoral enlargement. Some women can consume moderate doses of Stanozolol without such symptoms occurring. We can’t proclaim this the most female-friendly steroid, but it’s far from the unfriendliest.
If it is a steroid that is used and virilization symptoms begin to show if use is immediately discontinued, they will go away. If the symptoms are ignored and use continues there is a decent chance the symptoms may become permanent. The cardiovascular side effects of Stanozolol are the most likely and entail the most immense risk.
Stanozolol is properly-known for its ability to increase LDL cholesterol and reduce HDL cholesterol. Stanozolol is available in both oral and injectable forms, but in either case, it is a C17-aa steroid making the cardiovascular strain equal in both oral and injectable forms.
Stanozolol can be used without severe cardiovascular strain but should not be used if you hitherto have cholesterol issues. The use of Stanozolol will suppress natural testosterone production in all men and should purely be used in conjunction with exogenous testosterone. Failure to supplement with exogenous testosterone will place the man into a low testosterone state. The form of testosterone is inconsequential.
Once all Stanozolol use is ended and any anabolic steroids have cleared the body natural testosterone production will begin again. Women do not need to supplement with testosterone during Stanozolol use. This is one of the liver-toxic steroids available, far more so than Oxandrolone, but somewhat less than Methandrostenolone.
The use of Stanozolol will cause liver enzymes to increase during use. Increased enzyme levels are a liver stress indicator. This will hold equally true with both oral and injectable Stanozolol. Injectable Stanozolol is one of the very few injectable anabolic steroids that are liver toxic. No use should take place until liver enzymes have returned to normal. A liver detoxifying supplement should be used. A liver detoxifying supplement should be used.
CYCLES AND USAGE OF WINSTROL/STANOZOLOL
In therapeutic standards, Stanozolol is normally prescribed at a 2mg dose approximately three times per day for men. Women have typically prescribed two 2mg doses per day but may increase to 6mg if virilization symptoms are controlled.
If the physician opts for injectable Stanozolol, it is normally prescribed at 50mg per injection 2-3 times per week in both men and women. For the performance-enhancing athlete, 25-50mg doses on every other day to the daily basis are the most common among male athletes. Bodybuilders will typically administer 50mg.
It is not uncommon for doses to reach 100mg per day at the end of a cutting cycle, especially in competitive bodybuilding cycles but normally only the last 1-2 weeks before the competition. High-end doses that surpass this time frame will more than likely cause enormous amounts of liver strain. 5mg oral Stanozolol is the most common female dose. 5mg are all most women will need but some will increase it to 10mg per day if virilization is controllable.
Injectable Stanozolol is typically dosed at 20mg every 3-4 days, but oral is more desirable since it’s considerably easier to dose female-based amounts with the oral version. The oral desire has nothing to do with the effectiveness as both oral and injectable forms are equally effective.
HOW TO BUY OF WINSTROL/STANOZOLOL
Oral Winstrol can be found priced in the range of $1.50 – $3.00 per 50mg tablet. Keep in mind as well that Winstrol tablets can also be found in other concentrations (such as 5, 10, and 25mg tablets, etc.).
Injectable Winstrol can be found on the market anywhere from $60 – $120 for a 10ml vial with a standard concentration of 50mg/ml. Although 50mg/ml is a pharmaceutical standard for injectable Winstrol, many underground labs are now manufacturing higher concentrations and have been doing so for quite some time now. It is substantial to note, however, that such products with more excessive concentrations remain exclusively underground products – no human-grade pharmaceutical products are known to hold concentrations of greater than 50mg/ml.
Remember, this is a Class III controlled substance. It is not legal to buy this steroid in the United States without a prescription, so do not procure this drug illegally. And if you do buy it illegally, be warned that in some underground markets, you may be buying under-dosed or falsely dosed drugs that may not contain Stanozolol.
LATEST AND POSITIVE RESEARCH ON WINSTROL/STANOZOLOL
Stanozolol induces telomerase activity at a molecular level and exercise reverses this induction, at least regarding TERT expression. This may reflect premature tissue aging due to decreased telomerase activity Future studies are warranted in order to investigate the mechanisms through which exercise can be used to prevent the adverse health effects of stanazolol and elucidate the molecular hepatocellular mechanisms of the stanozolol-induced adverse effects.